I'm working on a speedrun for Nancy Drew: Legend of the Crystal Skull. Here are some things that I've found out.
1. If the first eyeball you get is the one in the trophy, Henry talks about it. If you get a different eyeball first, Henry doesn't say anything.
2. When Nancy first calls Bess, she mentions Renee and the tracing left behind by the Skeleton Man. But if you call Bess early on, before Nancy meets Renee or finds the tracing, Nancy doesn't mention those things.
3. Oddly enough, you don't need to make tracings, in order to solve the tracing puzzle. All you have to do is visit the mausoleum with charcoal and paper in your inventory. You can immediately turn around at that point and enter the tracing puzzle solution, without getting any of the tracings.
4. You don't need to look at the hoodoo symbols on Renee's wall, in order to solve the hoodoo puzzle. All you have to do is look in her book.