More information on Nancy Drew: Secrets Can Kill Remastered. Her Interactive has written all about the process of choosing a cover. It's pretty interesting to see the different changes that the cover went through.
Unfortunately, it looks like I'm wrong about Lucas from Days of Our Lives being on the cover. The person who's holding the football on the cover is Hector, the football player. Who knew?
Oh, and there's a new trailer that shows off the differences between the original version and the newer game: